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Epigenetic mechanisms see fact box control the activity of different genes. Disruptions in the epigenetic machinery may lead to diseases such as obesity and type 2 diabetes. This review summarises the role of epigenetic changes in different human tissues of relevance for metabolism, for example, in adipose tissue, skeletal muscle, pancreatic islets which, among other things, contain the insulin-producing cellsliver and blood, linked to obesity and type 2 diabetes. Similarly, the epigenetic patterns are affected by disease. Below is a summary of the latest findings within each category. The significance of diet.

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