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Animal Model. Genetic heterogeneity of human prothrombin FII. Several observations suggest that prothrombin may serve a broader physiologic role than Aplha stemming blood loss, including the identification of multiple G protein-coupled, thrombin-activated receptors, and the well-documented mitogenic activity of thrombin in in vitro test systems.
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AMY E.]Alternative titles; symbols. Cytogenetic location: Prothrombin is activated to the serine Alpha montessori house Herning thrombin by factor Xa F10; in the presence of phospholipids, calcium, and factor Va F5; The activated thrombin enzyme plays an important role in hemostasis and thrombosis: Degen and Davie determined the nucleotide sequence of the human prothrombin gene, which encodes a residue pre-propeptide with a molecular mass of about 70 kD.
The mature circulating protein has residues. The prothrombin protein contains 5 domains: The prothrombin protein undergoes several cleavage events to generate the active enzyme alpha-thrombin, which is composed of a light alpha and heavy beta chain covalently linked by a disulfide bond summary by Lancellotti and De Cristofaro, Degen et al.
Degen and Davie determined that the prothrombin gene contains 14 exons and spans about 21 kb.
Royle et al. Celikel et al. GP1BA occupancy may be sequential, as the site binding to alpha-thrombin exosite I appears to be cryptic in the unoccupied receptor but Hernint when a first thrombin molecule is bound through exosite II.
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Volunteer Opportunities. The Alpha Christian Children's Home was established in to help children who need a home or intervention in their lives. Alpha is Christian people working together to provide for children in need. Children can find open arms here with the love and care they need.
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